Cerebral atrophy in Parkinson's disease patients with visual hallucinations
Identifieur interne : 002A32 ( Main/Corpus ); précédent : 002A31; suivant : 002A33Cerebral atrophy in Parkinson's disease patients with visual hallucinations
Auteurs : B. Ramírez-Ruiz ; M. Martí ; E. Tolosa ; M. Giménez ; N. Bargall ; F. Valldeoriola ; C. JunquéSource :
- European Journal of Neurology [ 1351-5101 ] ; 2007-07.
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- KwdEn :
Abstract
Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non‐demented PD patients with VH using voxel‐based morphometry. Eighteen PD patients with VH were compared to 20 patients with PD without VH and 21 healthy controls. Compared with both controls and the non‐hallucinating PD group, PD patients with VH had grey matter volume reductions in the lingual gyrus and superior parietal lobe. Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients.
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DOI: 10.1111/j.1468-1331.2007.01768.x
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ISTEX:29A6963C46506C86A4546245EF20DC260F47FB5DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebral atrophy in Parkinson's disease patients with visual hallucinations</title><author><name sortKey="Ramirez Uiz, B" sort="Ramirez Uiz, B" uniqKey="Ramirez Uiz B" first="B." last="Ramírez-Ruiz">B. Ramírez-Ruiz</name><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Marti, M" sort="Marti, M" uniqKey="Marti M" first="M." last="Martí">M. 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The aim of this study was to investigate possible structural brain changes on MRI in non‐demented PD patients with VH using voxel‐based morphometry. Eighteen PD patients with VH were compared to 20 patients with PD without VH and 21 healthy controls. Compared with both controls and the non‐hallucinating PD group, PD patients with VH had grey matter volume reductions in the lingual gyrus and superior parietal lobe. Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>B. Ramírez‐Ruiz</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string><json:string>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string></affiliations></json:item><json:item><name>M.‐J. Martí</name><affiliations><json:string>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>E. Tolosa</name><affiliations><json:string>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>M. Giménez</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string><json:string>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string></affiliations></json:item><json:item><name>N. Bargalló</name><affiliations><json:string>Radiology Department, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>F. Valldeoriola</name><affiliations><json:string>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>C. 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The aim of this study was to investigate possible structural brain changes on MRI in non‐demented PD patients with VH using voxel‐based morphometry. Eighteen PD patients with VH were compared to 20 patients with PD without VH and 21 healthy controls. Compared with both controls and the non‐hallucinating PD group, PD patients with VH had grey matter volume reductions in the lingual gyrus and superior parietal lobe. Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>lingual gyrus</term></item><item><term>Parkinson's disease</term></item><item><term>superior parietal lobe</term></item><item><term>voxel‐based morphometry</term></item><item><term>visual hallucinations</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/29A6963C46506C86A4546245EF20DC260F47FB5D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="07007"><doi origin="wiley">10.1111/ene.2007.14.issue-7</doi><numberingGroup><numbering type="journalVolume" number="14">14</numbering><numbering type="journalIssue" number="7">7</numbering></numberingGroup><coverDate startDate="2007-07">July 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="7" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2007.01768.x</doi><idGroup><id type="unit" value="ENE1768"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2007-06-25"></event><event type="publishedOnlineFinalForm" date="2007-06-25"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="750">750</numbering><numbering type="pageLast" number="756">756</numbering></numberingGroup><correspondenceTo>Carme Junqué, Departament de Psiquiatria i Psicobiologia Clinica, Facultat de Medicina, Universitat de Barcelona, Casanova, 143, 08036 Barcelona, Spain (tel.: +34 93 402 45 70; fax: +34 93 403 52 94; e‐mail: <email>cjunque@ub.edu</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE1768.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 19 September 2006 Accepted 16 February 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Cerebral atrophy in Parkinson's disease patients with visual hallucinations</title><title type="shortAuthors">B. Ramírez‐Ruiz <i>et al.</i></title><title type="short">Brain atrophy in PD with visual hallucinations</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>B.</givenNames><familyName>Ramírez‐Ruiz</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3"><personName><givenNames>M.‐J.</givenNames><familyName>Martí</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2 #a3"><personName><givenNames>E.</givenNames><familyName>Tolosa</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a2"><personName><givenNames>M.</givenNames><familyName>Giménez</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>N.</givenNames><familyName>Bargalló</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2 #a3"><personName><givenNames>F.</givenNames><familyName>Valldeoriola</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1 #a2"><personName><givenNames>C.</givenNames><familyName>Junqué</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="ES"><unparsedAffiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="ES"><unparsedAffiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="ES"><unparsedAffiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="ES"><unparsedAffiliation>Radiology Department, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic de Barcelona, Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">lingual gyrus</keyword><keyword xml:id="k2">Parkinson's disease</keyword><keyword xml:id="k3">superior parietal lobe</keyword><keyword xml:id="k4">voxel‐based morphometry</keyword><keyword xml:id="k5">visual hallucinations</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non‐demented PD patients with VH using voxel‐based morphometry. Eighteen PD patients with VH were compared to 20 patients with PD without VH and 21 healthy controls. Compared with both controls and the non‐hallucinating PD group, PD patients with VH had grey matter volume reductions in the lingual gyrus and superior parietal lobe. Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cerebral atrophy in Parkinson's disease patients with visual hallucinations</title></titleInfo><titleInfo type="abbreviated"><title>Brain atrophy in PD with visual hallucinations</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cerebral atrophy in Parkinson's disease patients with visual hallucinations</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ramírez‐Ruiz</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.‐J.</namePart><namePart type="family">Martí</namePart><affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Tolosa</namePart><affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Giménez</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Bargalló</namePart><affiliation>Radiology Department, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Valldeoriola</namePart><affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Junqué</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-07</dateIssued><edition>Received 19 September 2006 Accepted 16 February 2007</edition><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent></physicalDescription><abstract lang="en">Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non‐demented PD patients with VH using voxel‐based morphometry. Eighteen PD patients with VH were compared to 20 patients with PD without VH and 21 healthy controls. Compared with both controls and the non‐hallucinating PD group, PD patients with VH had grey matter volume reductions in the lingual gyrus and superior parietal lobe. Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients.</abstract><subject lang="en"><genre>Keywords</genre><topic>lingual gyrus</topic><topic>Parkinson's disease</topic><topic>superior parietal lobe</topic><topic>voxel‐based morphometry</topic><topic>visual hallucinations</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>750</start><end>756</end><total>7</total></extent></part></relatedItem><identifier type="istex">29A6963C46506C86A4546245EF20DC260F47FB5D</identifier><identifier type="DOI">10.1111/j.1468-1331.2007.01768.x</identifier><identifier type="ArticleID">ENE1768</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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